DRUGS WITH ANTICHOLINERGIC PROPERTIES

MEDICATIONS WITH SIGNIFICANT ANTICHOLINERGIC PROPERTIES
Therapeutic Categories (Drug List*)	Potential Adverse Consequences
Antihistamines  • chlorpheniramine, cyproheptadine, diphenhydramine, hydroxyzine	Blood pressure, increased  Breathing difficulty, changes  Clumsiness or unsteadiness  Convulsions  Digestive system changes, e.g., • Bloating  • Bowel motility, decreased  • Constipation  • Ileus, paralytic/adynamic  • Nausea or vomiting  • Swallowing difficulty with dry mouth Mental status/behavior changes, e.g., • Distress, excitement, nervousness • Attention, impaired  • Cognitive decline  • Confusion/disorientation  • Hallucinations  • Memory loss  • Restlessness or irritability Delirium  Dizziness or Drowsiness  Fever  Headache  Heart rate, increased  Lethargy, fatigue  Mucous membrane dryness: mouth, nose  Muscle weakness, severe  Speech, slurring  Skin, changes • Dryness  • Sweating, decreased  • Flushing  • Warmth, excessive Vision impairment, changes in acuity • Blurring  • Glaucoma, worsening  • Eye pain  • Light sensitivity Urinary retention or difficulty By Akshaya Srikanth, Pharm.D Intern, India
Antidepressants  • amoxapine, amitriptyline, clomipramine, desipramine, doxepin, imipramine, nortriptyline, protriptyline, paroxetine
Antipsychotics  • chlorpromazine, clozapine, olanzapine, thioridazine
Antivertigo  • meclizine, scopolamine
Cardiovascular  • furosemide, digoxin, nifedipine, disopyramide
Gastrointestinal  • Antidiarrheal: diphenoxylate atropine  • Antispasmodics: belladonna, clidinium, chlordiazepoxide, dicyclomine, hyoscyamine, propantheline  • Antiulcer: cimetidine, ranitidine
Muscle Relaxants  • cyclobenzaprine, dantrolene, orphenadrine
Parkinsonism  • amantadine, benztropine, biperiden, trihexyphenidyl
Urinary Incontinence  • oxybutynin, propantheline, solifenacin, tolterodine, trospium ©akshaypharmd.blogspot.com